15 research outputs found

    The Concise Guide to PHARMACOLOGY 2023/24:Introduction and Other Protein Targets

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    The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16176. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are six areas of focus: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.</p

    THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets.

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    The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15537. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are six areas of focus: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate

    Competitiveness, Local Production Systems and Global Commodity Chains in the Music Industry: Entering the US Market

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    Power D. and Hallencreutz D. (2007) Competitiveness, local production systems and global commodity chains in the music industry: entering the US market, Regional Studies 41, -. This paper traces the principal channels and barriers that determine the conditions of access for musical products entering the US music market. It is shown that music distribution channels and retail environments exist in a networked commodity chain dominated by a limited set of oligopolistic global firms. The journey of a foreign musical product to market in the USA is a difficult one through a set of globally interlinked but highly fractured and localized commodity pools and channels. It is suggested that to understand success or failure in music sales and better develop regional production milieus, one must first understand those who control the distribution channels and retail environments through which sales are made. Power D. et Hallencreutz D. (2007) La competitivite, les systemes de production locaux et les chaines d'approvisionnement mondiales dans l'industrie de la musique: prendre pied sur le marche americain, Regional Studies 41, -. Cet article cherche a localiser les principaux circuits et barrieres qui determinent les conditions prealables a l'entree des produits de musique sur le marche de la musique americain. On demontre que les circuits de distribution de la musique et les surfaces de vente existent sous forme d'une chaine d'approvisionnement en reseau dominee par un nombre limite d'oligopoles mondiaux. Pour un produit de musique etranger, prendre pied sur le marche americain s'avere difficile, en passant par un nombre de bassins et de chaines d'approvisionnement relies sur le plan mondial mais a la fois hautement fissures et localises. L'article laisse supposer que, dans un premier temps, il faut comprendre ceux qui controlent les circuits de distribution et les surfaces de vente par lesquels les produits se vendent pour comprendre la reussite ou l'echec des ventes de musique et mieux developper l'espace de production regional. Industrie de la musique Geographie economique Marche de la musique americain Chaine d'approvisionnement Competitivite Systemes de production locaux Power D. und Hallencreutz D. (2007) Konkurrenzfahigkeit, lokale Produktionssysteme und globale Warenketten in der Musikindustrie: der Zugang zum Markt der USA, Regional Studies 41, -. In diesem Artikel werden die wichtigsten Kanale und Hindernisse beschrieben, die die Bedingungen festlegen, unter denen Musikprodukte auf den US-amerikanischen Musikmarkt gelangen. Es wird gezeigt, dass die Vertriebskanale und die Einzelhandelsumgebungen fur Musik in einer vernetzten Warenkette angesiedelt sind, die von einer kleinen Gruppe oligopolistischer globaler Konzerne beherrscht wird. Der Weg eines auslandischen Musikprodukts auf den Markt der USA steckt voller Schwierigkeiten und verlauft uber eine Reihe global verknupfter, aber hochgradig frakturierter und lokalisierter Warenpools und Kanale. Der Artikel legt den Schluss nahe, dass wir zunachst verstehen mussen, wer die Vertriebskanale und Einzelhandelsumgebungen kontrolliert, uber die der Absatz erzielt wird, wenn wir den Erfolg oder das Scheitern des Musikabsatzes verstehen und bessere lokale Produktionsmilieus entwickeln mochten. Musikindustrie Wirtschaftsgeografie Musikmarkt der USA Warenkette Konkurrenzfahigkeit Lokale Produktionssysteme Power D. y Hallencreutz D. (2007) Competitividad, sistemas de produccion local y cadenas globales de mercancias en la industria discografica: como entrar en el mercado estadounidense, Regional Studies 41, -. En este ensayo exploramos los principales canales y obstaculos que determinan cuales son las condiciones necesarias para que los productos musicales puedan llegar al mercado musical en los Estados Unidos. Demostramos que los canales de distribucion de las discograficas y los minoristas funcionan como una cadena de mercancias conectada y dominada por una serie limitada de empresas internacionales oligopolicas. El viaje que hace un producto musical extranjero hasta llegar al mercado estadounidense es un proceso dificil que tiene que pasar por una serie de consorcios y canales globalmente interconectados pero altamente fracturados y localizados. En este articulo sugerimos que para entender el exito o el fracaso de las ventas musicales y desarrollar mejor los medios de produccion regionales primero debemos conocer mejor quienes son los que controlan los canales de distribucion y los minoristas donde se hacen las ventas. Industria discografica Geografia economica Mercado discografico en Estados Unidos Cadena de mercancias Competitividad Sistemas locales de produccionMusic industry, Economic geography, US music market, Commodity chain, Competitiveness, Local production systems,

    From conception to consumption: creativity and the missing managerial link

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    Creative Labour provides an insight into the unique employment issues affecting workers in film, television, theatre, arts, music, radio and new media. In the UK alone, more than 1 million people work in the creative industries, generating billions of pounds in exports each year. These workers have to contend with elastic working hours, employment and promotion uncertainty and vigorous competition for each role. Creative Labour offers a contemporary perspective on a fascinating area of study and a rapidly growing area in developed economies. This chapter reviews the literature on creativity and the missing managerial link
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